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BISPHENOL A

CAS RN: 80-05-7

Synonyms: BPA, 4,4-Isopropylidenediphenol; 4,4'-methylethylidenebisphenol

Description: Used as a chemical intermediate, mainly for epoxy resins and polycarbonate resins. Used with epichlorohydrin to produce bisphenol-A diglycidyl ether, the monomer in bisphenol-A type epoxy resins. (Hazardous Substances Data Bank/NLM)

PBT

Not present on scanned chemical hazard lists as a PBT (Persistent/Bioaccumulative Toxicant).

Carcinogen
Not present on scanned chemical hazard lists as a carcinogen.

Mutagen

Reproductive
Probable or likely to be a reproductive toxicant.

Developmental
Known to be a developmental toxicant.

Endocrine

Other Chronic
Possibly an other chronic toxicant.

Acute

Ecotoxicant
Not present on scanned chemical hazard lists as an ecotoxicant.

Action List
Known to be an action listed chemical of concern.

Compound Groups

BISPHENOL A (BPA) COMPOUNDS [CMG10886]

Priority Level: Red -*- Material of very high concern due to cancer, mutation, reproductive/developmental harm, neurotox, endocrine disrupt. High priority to eliminate. -*- ------------------------------ -*- Listed Chemical of Concern - Action Plan published -*- ------------------------------ -*- US Environmental Protection Agency, Pollution Prevention & Toxics, Existing Chemicals Program (US EPA PPT)

Direct Hazard Warnings

Total warnings for BISPHENOL A: 9

A-Clear evidence of adverse developmental toxicant effects in humans or laboratory animals
US Dept of Health & Human Services, National Institutes of Health, National Institute of Environmental Health Sciences, National Toxicology Program (NTP),Center for the Evaluation of Risks to Human Reproduction (US NIH NTP )
Expert Panel Reports & Monographs on Reproductive and Developmental Toxicity (Repro & Developmental Monographs)

B-Some evidence of adverse reproductive toxicant effects in humans or laboratory animals
US Dept of Health & Human Services, National Institutes of Health, National Institute of Environmental Health Sciences, National Toxicology Program (NTP),Center for the Evaluation of Risks to Human Reproduction (US NIH NTP )
Expert Panel Reports & Monographs on Reproductive and Developmental Toxicity (Repro & Developmental Monographs)

Listed Chemical of Concern - Action Plan published
US Environmental Protection Agency, Pollution Prevention & Toxics, Existing Chemicals Program (US EPA PPT)
Chemicals of Concern Action Plans (Chemicals of Concern)

R37: Irritating to respiratory system.
European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Consumer Products Safety & Quality Unit (European Commission)
Substances with EU Risk & Safety Phrases (Commission Directive 67-548-EEC) (Risk Phrases)

R62: Possible risk of impaired fertility.
European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Consumer Products Safety & Quality Unit (European Commission)
Substances with EU Risk & Safety Phrases (Commission Directive 67-548-EEC) (Risk Phrases)

Category 1 - Evidence of endocrine disruption activity
European Commission, Council of the European Union DG ENV (European Commission)
EU Community Strategy for Endocrine Disrupters - Priority List (Endocrine Disrupters Strategy )

Endocrine disruptor - Substance of Possible Concern
Oslo-Paris Convention Commission (OSPAR)
Chemical Lists of Priority Action & Possible Concern (Priority PBTs & EDs & equivalent concern)

R41: Risk of serious damage to eyes.
European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Consumer Products Safety & Quality Unit (European Commission)
Substances with EU Risk & Safety Phrases (Commission Directive 67-548-EEC) (Risk Phrases)

R43: May cause sensitization by skin contact.
European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Consumer Products Safety & Quality Unit (European Commission)
Substances with EU Risk & Safety Phrases (Commission Directive 67-548-EEC) (Risk Phrases)

Life Cycle (chemicals used or emitted in the life cycle of BISPHENOL A)

This list of chemicals is not exhaustive of all chemicals that may be involved in the production or life cycle of this substance.

PHENOL [108-95-2]

Role in manufacture: Integral Monomer.
Emitted during manufacture: Unknown. No known data or unclear data.
Exposure in use: Unknown. No known data or unclear data.
Exposure in degradation: Unknown. No known data or unclear data.
Exposure in combustion: Unknown. No known data or unclear data.

ACETONE [67-64-1] Priority Level: Orange -*- Material of high concern - possible CMR toxicity or respiratory. Next priority for substitution. -*- ------------------------------ -*- known to be neurotoxic in man -*- ------------------------------ -*- Lancet: authors Philippe Grandjean & Phil Landrigan (Lancet)

Priority Level: Yellow -*- Material of moderate concern or preliminary data of high concern. Avoid when possible. -*- ------------------------------ -*- R36: Irritating to eyes. -*- ------------------------------ -*- European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Consumer Products Safety & Quality Unit (European Commission)

Role in manufacture: Integral Monomer.
Emitted during manufacture: Unknown. No known data or unclear data.
Exposure in use: Unknown. No known data or unclear data.
Exposure in degradation: Unknown. No known data or unclear data.
Exposure in combustion: Unknown. No known data or unclear data.

HYDROGEN CHLORIDE (HCL) [7647-01-0] Priority Level: Orange -*- Material of high concern - possible CMR toxicity or respiratory. Next priority for substitution. -*- ------------------------------ -*- ARr: known asthmagen - reviewed by AOEC and meets RADS criteria -*- ------------------------------ -*- Association of Occupational and Environmental Clinics (AOEC)

Priority Level: Orange -*- Material of high concern - possible CMR toxicity or respiratory. Next priority for substitution. -*- ------------------------------ -*- ARr: known asthmagen - reviewed by AOEC and meets RADS criteria -*- ------------------------------ -*- Association of Occupational and Environmental Clinics (AOEC)

Priority Level: Yellow -*- Material of moderate concern or preliminary data of high concern. Avoid when possible. -*- ------------------------------ -*- R35: Causes severe burns. -*- ------------------------------ -*- European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Consumer Products Safety & Quality Unit (European Commission)

Role in manufacture: Frequent Intermediate.
Emitted during manufacture: Unknown. No known data or unclear data.
Exposure in use: Unknown. No known data or unclear data.
Exposure in degradation: Unknown. No known data or unclear data.
Exposure in combustion: Unknown. No known data or unclear data.