pharos project : : chemical and material library : chemical profile

Preview of a Pharos Chemical and Material Library Profile

This is a typical chemical profile in the Pharos Chemical and Material Library (CML). If you are not yet a subscriber, register for a free trial subscription.

DI(2-ETHYLHEXYL)PHTHALATE (DEHP)

CAS RN: 117-81-7

Synonyms: Dioctyl Phthalate (DOP), n-Dioctyl phthalate, dioctylphthalate, bis(2-ethylhexyl) phthalate

Description: Primarily used as a plasticizer for polyvinyl chloride (PVC)in flooring, roofing, siding, packaging and more. Also more rarely used as a plasticizer in synthetic rubber and other plastics.
Di(2-ethylhexyl) phthalate is produced commercially by the reaction of excess 2-ethylhexanol with phthalic anhydride in the presence of an acid catalyst such as sulfuric acid or para-toluenesulfonic acid. Note: "There may be some ambiguity in the literature and in common usage for the nomenclature of the isomers bis(2-ethylhexyl) phthalate (DEHP), bis(6-methylheptyl) phthalate (also known as diisooctyl phthalate or DIOP), di-n-octyl phthalate (DnOP), and the non-isomer-specific term "dioctylphthalate (DOP)". (Hazardous Substances Data Bank) Additional overview information available from: http://www.atsdr.cdc.gov/toxprofiles/tp9.pdf

More information: www.pharosproject.net/wiki/index.php?title=Phthalates

PBT

Known to be a PBT (Persistent/Bioaccumulative Toxicant).

Carcinogen
Known to be a carcinogen.

Mutagen

Reproductive
Known to be a reproductive toxicant.

Developmental
Known to be a developmental toxicant.

Endocrine

Other Chronic
Possibly an other chronic toxicant.

Acute

Ecotoxicant
Not present on scanned chemical hazard lists as an ecotoxicant.

Action List
Known to be an action listed chemical of concern.

Compound Groups

PHTHALATES [CMG10535]

Priority Level: Red -*- Material of very high concern due to cancer, mutation, reproductive/developmental harm, neurotox, endocrine disrupt. High priority to eliminate. -*- ------------------------------ -*- Listed Chemical of Concern - Action Plan published -*- ------------------------------ -*- US Environmental Protection Agency, Pollution Prevention & Toxics, Existing Chemicals Program (US EPA PPT)

Priority Level: Orange -*- Material of high concern - possible CMR toxicity or respiratory. Next priority for substitution. -*- ------------------------------ -*- Significant indications that this chemical is an asthmagen or bronchial irritant -*- ------------------------------ -*- Healthy Building Network (HBN)

Direct Hazard Warnings

Total warnings for DI(2-ETHYLHEXYL)PHTHALATE (DEHP): 19

PBT - Chemical for Priority Action
Oslo-Paris Convention Commission (OSPAR)
Chemical Lists of Priority Action & Possible Concern (Priority PBTs & EDs & equivalent concern)

R60: May impair fertility.
European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Consumer Products Safety & Quality Unit (European Commission)
Substances with EU Risk & Safety Phrases (Commission Directive 67-548-EEC) (Risk Phrases)

R61: May cause harm to the unborn child.
European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Consumer Products Safety & Quality Unit (European Commission)
Substances with EU Risk & Safety Phrases (Commission Directive 67-548-EEC) (Risk Phrases)

1986 Guidelines Group B2: Probable human carcinogen- based on sufficient evidence of carcinogenicity in animals
US Environmental Protection Agency, National Center for Environmental Assessment (US EPA NCEA)
Integrated Risk Information System Database (IRIS Carcinogens)

Cancer
State of California Environmental Protection Agency, Office of Environmental Health Hazard Assessment (OEHHA) (CAL-EPA )
Chemicals Known to the State to Cause Cancer or Reproductive Toxicity - California Proposition 65 -Safe Drinking Water and Toxic Enforcement Act Of 1986 (Prop 65)

Developmental
State of California Environmental Protection Agency, Office of Environmental Health Hazard Assessment (OEHHA) (CAL-EPA )
Chemicals Known to the State to Cause Cancer or Reproductive Toxicity - California Proposition 65 -Safe Drinking Water and Toxic Enforcement Act Of 1986 (Prop 65)

OSHA Carcinogen listed
US EPA & US Department of Labor, Occupational Safety and Health Administration (US OSHA)
TRI Carcinogens (Carcinogens)

Reproduction Category 2: should be regarded as if they impair fertility to humans or cause developmental toxicity to humans
European Commission, Enterprise and Industry DG (European Commission)
Annex I of Directive 76/769/EEC - Carcinogens, Mutagens, & Toxic for Reproduction (Directive 76/769 CMR)

Male - reproductive
State of California Environmental Protection Agency, Office of Environmental Health Hazard Assessment (OEHHA) (CAL-EPA )
Chemicals Known to the State to Cause Cancer or Reproductive Toxicity - California Proposition 65 -Safe Drinking Water and Toxic Enforcement Act Of 1986 (Prop 65)

Reasonably Anticipated to be Human Carcinogens
US Dept of Health & Human Services, National Institutes of Health, National Institute of Environmental Health Sciences, National Toxicology Program (US NIH NTP)
11th Report on Carcinogens (RoC)

Toxic to reproducton - Prioritized for listing in Annex XIV
European Union - European Chemicals Agency (ECHA)
Candidate List of Substances of Very High Concern for authorisation - REACH Annex XIV (REACH SVHC)

Endocrine disruptor - Chemical for Priority Action
Oslo-Paris Convention Commission (OSPAR)
Chemical Lists of Priority Action & Possible Concern (Priority PBTs & EDs & equivalent concern)

A-Clear evidence of adverse developmental toxicant effects in humans or laboratory animals
US Dept of Health & Human Services, National Institutes of Health, National Institute of Environmental Health Sciences, National Toxicology Program (NTP),Center for the Evaluation of Risks to Human Reproduction (US NIH NTP )
Expert Panel Reports & Monographs on Reproductive and Developmental Toxicity (Repro & Developmental Monographs)

A-Clear evidence of adverse reproductive toxicant effects in humans or laboratory animals
US Dept of Health & Human Services, National Institutes of Health, National Institute of Environmental Health Sciences, National Toxicology Program (NTP),Center for the Evaluation of Risks to Human Reproduction (US NIH NTP )
Expert Panel Reports & Monographs on Reproductive and Developmental Toxicity (Repro & Developmental Monographs)

Listed Chemical of Concern - Action Plan published
US Environmental Protection Agency, Pollution Prevention & Toxics, Existing Chemicals Program (US EPA PPT)
Chemicals of Concern Action Plans (Chemicals of Concern)

Category 1 - Evidence of endocrine disruption activity
European Commission, Council of the European Union DG ENV (European Commission)
EU Community Strategy for Endocrine Disrupters - Priority List (Endocrine Disrupters Strategy )

Listed Hazardous Air Pollutant
US Environmental Protection Agency, Technology Transfer Network (US EPA TTN )
Clean Air Act Amendments of 1990 List of Hazardous Air Pollutants (HAPs)

Significant indications that this chemical is an asthmagen or bronchial irritant
Healthy Building Network (HBN)
Precautionary Chemical Hazard List (Precaution)

Group 3: Agent is not classifiable as to its carcinogenicity to humans
International Agency for Research on Cancer, World Health Organization (IARC)
Monographs On the Evaluation of Carcinogenic Risks to Humans (Cancer Monographs)

Life Cycle (chemicals used or emitted in the life cycle of DI(2-ETHYLHEXYL)PHTHALATE (DEHP))

This list of chemicals is not exhaustive of all chemicals that may be involved in the production or life cycle of this substance.

PHTHALIC ANHYDRIDE [85-44-9] Priority Level: Orange -*- Material of high concern - possible CMR toxicity or respiratory. Next priority for substitution. -*- ------------------------------ -*- R37: Irritating to respiratory system. -*- ------------------------------ -*- European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Consumer Products Safety & Quality Unit (European Commission)

Role in manufacture: Integral Monomer.
Emitted during manufacture: Unknown. No known data or unclear data.
Exposure in use: Unknown. No known data or unclear data.
Exposure in degradation: Unknown. No known data or unclear data.
Exposure in combustion: Unknown. No known data or unclear data.

2-ETHYL-1-HEXANOL [104-76-7]

Role in manufacture: Integral Monomer.
Emitted during manufacture: Unknown. No known data or unclear data.
Exposure in use: Unknown. No known data or unclear data.
Exposure in degradation: Unknown. No known data or unclear data.
Exposure in combustion: Unknown. No known data or unclear data.

SULFURIC ACID [7664-93-9] Priority Level: Orange -*- Material of high concern - possible CMR toxicity or respiratory. Next priority for substitution. -*- ------------------------------ -*- ARr: known asthmagen - reviewed by AOEC and meets RADS criteria -*- ------------------------------ -*- Association of Occupational and Environmental Clinics (AOEC)

Priority Level: Orange -*- Material of high concern - possible CMR toxicity or respiratory. Next priority for substitution. -*- ------------------------------ -*- ARr: known asthmagen - reviewed by AOEC and meets RADS criteria -*- ------------------------------ -*- Association of Occupational and Environmental Clinics (AOEC)

Priority Level: Yellow -*- Material of moderate concern or preliminary data of high concern. Avoid when possible. -*- ------------------------------ -*- R35: Causes severe burns. -*- ------------------------------ -*- European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Consumer Products Safety & Quality Unit (European Commission)

Role in manufacture: Frequent Catalyst.
Emitted during manufacture: Unknown. No known data or unclear data.
Exposure in use: Unknown. No known data or unclear data.
Exposure in degradation: Unknown. No known data or unclear data.
Exposure in combustion: Unknown. No known data or unclear data.

P-TOLUENESULFONIC ACID [104-15-4] Priority Level: Orange -*- Material of high concern - possible CMR toxicity or respiratory. Next priority for substitution. -*- ------------------------------ -*- R37: Irritating to respiratory system. -*- ------------------------------ -*- European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Consumer Products Safety & Quality Unit (European Commission)

Priority Level: Yellow -*- Material of moderate concern or preliminary data of high concern. Avoid when possible. -*- ------------------------------ -*- R36: Irritating to eyes. -*- ------------------------------ -*- European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Consumer Products Safety & Quality Unit (European Commission)

Role in manufacture: Frequent Catalyst.
Emitted during manufacture: Unknown. No known data or unclear data.
Exposure in use: Unknown. No known data or unclear data.
Exposure in degradation: Unknown. No known data or unclear data.
Exposure in combustion: Unknown. No known data or unclear data.

BENZENE [71-43-2] Priority Level: Red -*- Material of very high concern due to cancer, mutation, reproductive/developmental harm, neurotox, endocrine disrupt. High priority to eliminate. -*- ------------------------------ -*- 1996 Guidelines: Known/likely human carcinogen -*- ------------------------------ -*- US Environmental Protection Agency, National Center for Environmental Assessment (US EPA NCEA)

Role in manufacture: Occasional/rare Intermediate.
Emitted during manufacture: Unknown. No known data or unclear data.
Exposure in use: Unknown. No known data or unclear data.
Exposure in degradation: Unknown. No known data or unclear data.
Exposure in combustion: Unknown. No known data or unclear data.